CDC4 — Schizosaccharomyces pombe 972h-

Summary

SPBC1718.01 (CDC4, pop1) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with F-box and WD40 repeat domains that acts as a ubiquitin ligase substrate adaptor and molecular sensor. It binds U3 snoRNA, dynein complex, microtubule plus-ends, ubiquitin, GTP, and identical proteins. The gene is associated with negative regulation of mitotic DNA replication initiation, regulation of cell division, contractile ring assembly, microtubule organizing center organization, vesicle transport along microtubule, G2 phase, anaphase-promoting complex-dependent catabolic process, SCF-dependent proteasomal ubiquitin-dependent protein breakdown, G1/S transition, and rRNA processing. It localizes to the SCF complex, 90S preribosome, SSU processome, kinetochore, nuclear envelope, and microtubule-associated complex. Associations include increased mating type switching, absent mating efficiency, abnormal cell cycle progression, altered pheromone response, delayed chromosome segregation, increased sporulation, and effects on germination rate.