ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC1734.11 (ARK1, also known as mas5) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a DnaJ/Hsp40 family protein with a DNJA1/2-like domain. The gene product exhibits heat shock protein binding, Hsp70 protein binding, ATPase activator activity, protein sequestering activity, and zinc and ATP binding. ARK1 is associated with cellular responses to misfolded proteins, de novo protein folding, protein quality control, and protein aggregate center assembly. It is linked to chromosome segregation, centrosome duplication, centromere localization, sister chromatid segregation, and chromosome condensation. The gene is associated with TORC2 signaling, galactose-specific flocculation, microtubule shortening, and mitochondrial outer membrane protein import. Phenotypic associations include decreased cytokinesis, delayed G2 phase cell cycle progression, decreased endocytosis, abnormal filamentous growth, decreased pheromone sensitivity, and increased polyploidy.