CKS1 — Schizosaccharomyces pombe 972h-

Summary

SPBC1734.14C (CKS1, suc1) on chromosome 2 of Schizosaccharomyces pombe encodes a cyclin-dependent kinase regulatory subunit that belongs to the cyclin-dependent kinase regulator subunit superfamily. The product possesses cyclin-dependent protein serine/threonine kinase activator activity and binds protein complexes, protein kinases, ubiquitin, histones, and zinc. CKS1 is associated with the SCF complex and CDK holoenzyme, localises to the cytosol and nucleus, and is linked to mitotic cell cycle progression, including metaphase, anaphase, spindle elongation, and mitotic exit. The gene has been connected to endosperm development, pollination, embryogenesis, syngamy, and responses to nerve growth factor and EGF stimulus. Associations with leaf size, acid sensitivity, oxidative stress response, and numerous cell cycle phenotypes—including altered G2/M phase transition, chromosome segregation, sporulation, and mating type switching—have been observed.