spo6 — Schizosaccharomyces pombe 972h-

Summary

SPBC1778.04 (spo6) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with a DBF4 zinc finger domain and a BRCT domain, possessing protein serine/threonine kinase activator activity, nucleic acid binding, and zinc binding. It is associated with positive regulation of DNA replication initiation, premeiotic DNA replication, and the intra-S DNA damage checkpoint. The gene is linked to meiotic processes including meiosis I and II, meiotic spindle assembly, ascospore formation, sporulation, mating, and sexual reproduction. It localises to the nucleoplasm, mitotic spindle pole body, cytosol, and nucleus. Related genes in other species link the family to replication regulation.