hop1 — Schizosaccharomyces pombe 972h-

Summary

SPBC1718.02 (hop1) on chromosome 2 of Schizosaccharomyces pombe encodes a HORMA-domain protein with ubiquitin-like protein ligase activity, DNA binding and zinc binding. The product is associated with linear elements and is linked to meiotic DNA double-strand break formation involved in reciprocal meiotic recombination, strand invasion, the pachytene checkpoint, and homologous recombination. The gene has been connected to DNA damage checkpoint control, double-strand break repair, sumoylation, sporulation, meiosis, mitosis, autophagy, the glucose effect, and cell cycle progression.