ASPA — Schizosaccharomyces pombe 972h-

Summary

SPBC16A3.01 (symbol ASPA, also known as spn3 and CDC11) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a septin family protein with GTPase activity, structural constituent of the cytoskeleton, and binding to phosphatidylinositol-5-phosphate, phosphatidylinositol-4-phosphate, and lipid. The gene is associated with mitotic prometaphase, the mitotic spindle checkpoint, bipolar cell growth, cytoskeleton-dependent cytokinesis, septin ring disassembly, contractile ring assembly, and regulation of mitosis. It is linked to cell cycle progression through G2/M phase transition, anaphase arrest, chromosome segregation, and telomere length. Associations also include protein content, fermentative growth, hyperosmotic stress resistance, and prion inheritance. The gene localizes to the cellular bud neck septin structure, hyphal septin ring, meiotic septin complex, and prospore septin ring. Related genes in other species link the family to reduced virulence and salt tolerance.