HST1 — Schizosaccharomyces pombe 972h-

Summary

SPBC16D10.07C (HST1, sir2) in Schizosaccharomyces pombe 972h- encodes a sirtuin-family NAD-dependent histone deacetylase with activity on histones H3K4, H3K9, H3K14 and H4K16, and is associated with transcription corepressor activity. The gene is associated with constitutive heterochromatin and subtelomeric heterochromatin assembly, suppression of telomeric recombination, downregulation of mitotic and meiotic recombination, and regulation of thiamine anabolism. It localises to nuclear lumen, centric heterochromatin, mating-type region heterochromatin, and the SET3C complex. Phenotypic associations link HST1 to cell cycle progression delays in G1/S and G2 phases, loss of oxidative stress resistance, increased gamma ray resistance, increased virulence, absent biofilm formation, abnormal flocculation, and increased sporulation rate. Studies of related genes in other species connect it to oxidative stress response.