fkh2 — Schizosaccharomyces pombe 972h-

Summary

SPBC16G5.15C (fkh2) on chromosome 2 of Schizosaccharomyces pombe encodes a forkhead transcription factor, containing a forkhead DNA-binding domain and an FHA domain, and is annotated with bis(5'-nucleosyl)-tetraphosphatase and ADP:sulfate adenylyltransferase activities. The gene is associated with DNA-binding transcription factor activity, both activator and repressor functions for RNA polymerase II, and sequence-specific DNA binding. It is linked to the regulation of cell cycle switching between mitotic and meiotic cycles, including negative regulation of the mitotic-to-meiotic switch, entry into the meiotic cell cycle, meiotic S phase, and meiosis II. Additional associations include mRNA stabilization, positive regulation of ribosomal protein gene transcription, rRNA transcription, division septum assembly, and immune response. The protein localizes to the nucleus and chromatin. Studies of related genes in other species link the family to loss of pathogenicity.