CP1 — Schizosaccharomyces pombe 972h-

Summary

SPBC16G5.09 (CP1) on chromosome 2 of Schizosaccharomyces pombe encodes a serine carboxypeptidase (EC 3.4.16.6) belonging to the peptidase S10 and alpha/beta hydrolase families. The gene is associated with spindle localization, microtubule bundling, nucleation and sliding, mitotic spindle assembly and elongation, septum positioning, nuclear movement, chromatin silencing, and cellular senescence. It is linked to protein processing, intracellular transport, and localization to the trans-Golgi network and vacuolar membrane. Phenotypic associations include altered entry into G0, acquired thermotolerance, abnormal autophagy and mitophagy, increased aneuploidy, abnormal nuclear fusion during mating, and effects on cell death, lifespan, prion inheritance, and protein secretion. The gene is also associated with floral and organ identity traits.