php4 — Schizosaccharomyces pombe 972h-

Summary

SPBC16E9.01C (php4) in Schizosaccharomyces pombe 972h- encodes a protein with a Hap4_TF_heteromerisation domain and is annotated as a transcription corepressor. It is associated with the CCAAT-binding factor complex and localises to the nucleus, cytoplasm, cytosol, spindle pole, and mitotic spindle. The gene is linked to cellular iron ion homeostasis, iron transport, response to iron, iron-sulfur cluster assembly, heme anabolism, and ferroptosis. It has also been connected to TCA cycle, oxidative phosphorylation, mitochondrial translation, amino acid anabolism, NO storage, nuclear import and export, metaphase, meiosis, cell death, and negative regulation of transcription by RNA polymerase II. Additionally, php4 is associated with the oxidative stress response.