HSP98 — Schizosaccharomyces pombe 972h-

Summary

SPBC16D10.08C (HSP98) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with ClpR_N, Clp_N_dom_sf, ClpA/ClpB_AAA_lid, ClpA/B_CS1, ClpA/B_CS2, ClpA_ClpB, Clp_ATPase_C, ClpA/B, ATPase_AAA_core, AAA+_ATPase, and P-loop_NTPase domains. It is associated with misfolded protein binding, ATP-dependent protein disaggregase activity, chaperone protein binding, ATP hydrolase activity, and ATP binding. The gene is associated with cellular response to misfolded protein, cellular thermotolerance, protein stabilization, protein unfolding, translation termination, protein refolding, cellular response to heat, protein folding, protein breakdown, cell death, cell division, and cell growth. It is linked to oxidative stress response and has been associated with abnormal nitrogen utilization, increased prion inheritance, altered chemical compound excretion, and absent fermentative metabolism. The protein localizes to the cytoplasm, cytosol, nucleus, nuclear envelope, mitochondrial lumen, and protein aggregate centers. Related genes in other species link the family to heat shock proteins.