KIP3 — Schizosaccharomyces pombe 972h-

Summary

SPBC1685.15C, also known as KIP3 or klp6 in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a kinesin motor domain protein with microtubule motor activity, plus-end-directed microtubule motor activity, microtubule lateral and plus-end binding, ATP hydrolase activity, and ATP binding. This gene is associated with metaphase chromosome alignment, protein transport along microtubules to cell tips and kinetochores, spindle positioning, lateral attachment of mitotic spindle microtubules to kinetochores, plus-end-specific microtubule depolymerization, mitotic chromosome movement to spindle poles, centromere localization, initial mitotic spindle pole body separation, and microtubule nucleation. It is linked to phenotypes including cell cycle delays and arrests in metaphase and anaphase, abnormal nuclear fusion during mating, increased polyploidy and aneuploidy, decreased chromosome segregation, increased pheromone sensitivity, abnormal septum formation, and increased fermentative metabolism. The protein localizes to microtubule ends, the kinesin I complex, and mitotic spindle astral and polar microtubules.