DSPD — Schizosaccharomyces pombe 972h-

Summary

SPBC1685.01 (DSPD, also known as pmp1) on chromosome 2 of Schizosaccharomyces pombe encodes a dual-specificity MAP kinase phosphatase with EC 3.1.3.48 activity. The product belongs to the dual-specificity phosphatase catalytic domain family and possesses protein tyrosine/threonine phosphatase activity. This gene is associated with negative regulation of the cell integrity MAPK cascade, downregulation of the MAPK cascade, and stress-activated MAPK cascade processes. It is linked to mRNA destabilization and stabilization, posttranscriptional regulation of gene expression, and SG assembly. Additional associations include negative regulation of filamentous growth, glucan anabolism, pheromone response, cytokinesis, nuclear export, and response to stress. The protein localizes to the cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence.