GAP1 — Schizosaccharomyces pombe 972h-

Summary

SPBC1652.02 (GAP1) on chromosome 2 of Schizosaccharomyces pombe encodes an amino acid permease belonging to the APC/YAT family, with L-arginine and L-lysine transporter activity and mechanically-gated cation channel activity. The gene is associated with L-lysine, L-leucine and L-arginine import, basic amino acid transport, cell-cell fusion, regulation of growth, Ras protein signal transduction, replication fork arrest, regulation of cytokinesis, nucleosome assembly, digestion, cellular response to stress, interphase, and regulation of nitrogen utilization. The protein localizes to the plasma membrane at cell tips, the medial membrane band, cell division site, Golgi membrane, endoplasmic reticulum, and fungal-type vacuole. Phenotypic associations include altered hydrostatic pressure resistance, nutrient uptake, endocytosis, cell cycle progression, spore germination, sporulation, cell death, replicative lifespan, carbon and nitrogen source utilization, and plasma membrane morphology.