CDS1 — Schizosaccharomyces pombe 972h-

Summary

SpCDS1 (CDS1) on chromosome 2 of Schizosaccharomyces pombe encodes a CDP-diglyceride synthase (EC 2.7.7.41) with a PC_trans domain, localised to the endoplasmic reticulum membrane. This enzyme is associated with CDP-diacylglycerol anabolism. The gene is associated with DNA integrity checkpoint, mitotic and meiotic S phases, pachytene, establishment of sister chromatid cohesion, rDNA maintenance, and responses to ionizing radiation, UV, cisplatin, and hydroxyurea. It is also linked to protein kinase A activation, trans-autophosphorylation, microtubule stabilisation, and regeneration. Phenotypic associations include abnormal or absent meiosis and sporulation, altered cell cycle progression (notably G2/M phase delay), increased cell size, increased or decreased X-ray resistance, increased mutation frequency, altered mitochondrial morphology and transport, increased stress resistance, increased biofilm and filamentous growth, and increased replicative lifespan. Studies of related genes in other species link the family to hyperosmotic stress resistance and endoplasmic reticulum morphology.