ASH2 — Schizosaccharomyces pombe 972h-

Summary

SPBC13G1.08C (ASH2) in Schizosaccharomyces pombe 972h- encodes a protein with an ASH2-like PHD finger and SPRY domain, and is annotated to transcription cis-regulatory region binding and zinc binding. The gene is associated with epigenetic regulation of gene expression, including chromatin-mediated maintenance of transcription, telomeric silencing, and downregulation of gene expression. It is linked to mating type switching, sporulation, meiosis, mitosis, DNA replication, methylation, and protein phosphorylation. ASH2 is also connected to chromatin and nuclear localisation, particularly telomeric regions. Phenotypic associations include abnormal cell cycle progression, increased polyploidy and aneuploidy, increased meiotic recombination, decreased colony size, and altered budding patterns. Studies of related genes in other species link the family to oxidative stress response and reduced virulence.