klp9 — Schizosaccharomyces pombe 972h-

Summary

SPBC15D4.01C (klp9) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes a kinesin-like motor protein with ATP hydrolase activity and microtubule motor activity, capable of both plus-end- and minus-end-directed movement along microtubules. The gene is associated with multiple aspects of mitotic and meiotic spindle dynamics, including anaphase spindle elongation, spindle midzone assembly, spindle pole body separation, and chromosome movement to the spindle pole. It is linked to sister chromatid segregation, kinetochore retrieval, microtubule depolymerization, and cytoskeleton-dependent intracellular transport. Localization evidence links the product to polar, astral, and cortical microtubules, the kinesin I complex, and the meiotic spindle midzone and pole. Related genes in other species further connect the family to microtubule-based transport and cell division processes.