ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC1271.10C (ARK1, also known as SpARK1 or PRK1) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes an uncharacterized MFS-type transporter with polyamine transmembrane transporter activity and threonine efflux permease activity. The gene is associated with intracellular polyamine homeostasis, amino acid efflux, and transmembrane transport of spermidine. It is also associated with regulation of chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, chromosome condensation, microtubule shortening, meiosis II, telophase, TORC2 signaling, lipid raft assembly, galactose-specific flocculation, and protein positioning. The product localizes to the peroxisome membrane, cell cortex, endoplasmic reticulum, and plasmalemma. Phenotypic associations include decreased rates of cytokinesis, endocytosis, and bipolar budding, delayed G2 phase progression, increased polyploidy, and abnormal filamentous growth, pseudohyphal growth, and shmoo formation.