ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC11B10.09 (ARK1, also known as cdc2) on chromosome 2 of Schizosaccharomyces pombe encodes a cyclin-dependent protein kinase (EC 2.7.11.22) with CDK activity, protein serine/threonine kinase activity, and binding capabilities for cyclins, RNA polymerase II core, histones, and ATP. This gene is associated with regulation of the cell cycle, including negative regulation of cell cycle progression, mitotic metaphase and S phase, chromosome segregation, and cytokinesis. It is linked to cell tip growth, embryogenesis, oogenesis, hemopoiesis, and responses to ionizing radiation and hydrostatic pressure. Associations with traits include cell membrane stability and protein content. Phenotypic associations include delayed G2 phase cell cycle progression, arrested S phase, decreased endocytosis, abnormal filamentous and pseudohyphal growth, increased polyploidy, and decreased necrotic cell death. The protein localizes to CDK holoenzyme complexes, meiotic and mitotic spindles, spindle pole bodies, and telomeric regions.