ABP1 — Schizosaccharomyces pombe 972h-

Summary

SPAPJ760.02C (ABP1) in Schizosaccharomyces pombe 972h- encodes a protein with actin-binding, F-actin-binding, ubiquitin-binding, diacylglycerol-binding, and cytoskeletal protein-membrane anchor activities, containing ADF-H, SH3, and gelsolin-like domains. The gene is associated with actin cortical patch assembly, actin polymerization and filament branch nucleation, endocytosis, cell cycle control, cytokinesis, spindle assembly, and cell division site localization. It is linked to mating-type switching, sex determination, donor selection, gene conversion, and suppression of meiotic recombination, as well as heterochromatin organization, nucleosome assembly, centromeric silencing, and chromatin silencing. Phenotypic associations include abnormal filamentous growth, shmoo formation, spore wall formation, chitin deposition, septum formation, cell fusion, and prion inheritance, along with decreased endocytosis, cytokinesis rate, adhesion, and fermentative metabolism, and increased alkaline pH resistance and respiratory metabolism.