KDX1 — Schizosaccharomyces pombe 972h-

Summary

SPBC119.08, also known as KDX1 or pmk1 in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a mitogen-activated protein (MAP) kinase with serine/threonine kinase activity (EC 2.7.11.24), classified as an ERK1-type kinase. It possesses ATP binding and ATP-dependent protein binding functions. This gene is associated with the SAPK signaling pathway, regulation of melanin anabolism, and positive regulation of appressorium formation. It is linked to mitotic anaphase, cell cycle progression, and septum formation, with connections to decreased cell cycle rate and delayed telophase progression. Associations include response to salt stress, oxidative stress response, cellular thermotolerance, and turgor pressure. The protein localizes to the mitotic spindle pole body, cell division site, cytoplasm, cytosol, and nucleus. Related genes in other species link it to cell integrity MAPK cascades and virulence traits.