DCR1 — Schizosaccharomyces pombe 972h-

Summary

SPBC119.11C (DCR1, also known as pac1) on chromosome 2 of Schizosaccharomyces pombe encodes a ribonuclease III enzyme with dsRNA-specific RNase activity, RNA hairpin binding, rDNA binding, and metal binding. The protein contains an Rnt1/Pac1_DSRM_fungi domain, a dsRBD domain, and an RNase III domain. DCR1 is associated with snRNA metabolism, U2 and U4 snRNA 3'-end processing, box C/D snoRNA 5'-end processing, RNA surveillance, nuclear mRNA breakdown, and RNA-dependent gene silencing. It is linked to posttranscriptional regulation of gene expression, termination of RNA polymerase II transcription, centromeric silencing, and rDNA maintenance. The gene is associated with cell cycle regulation including S-M checkpoint control, cell quiescence, and G2 phase progression. Phenotypic associations include absent meiosis, absent mating type switching, decreased budding, abnormal cytokinesis, increased fermentative metabolism, and altered stress resistance. The protein localizes to the nucleoplasm, nucleolus, and nucleus.