mph1 — Schizosaccharomyces pombe 972h-

Summary

mph1 (SPBC106.01) on chromosome 2 of Schizosaccharomyces pombe 972h- encodes a dual-specificity protein kinase with MAPKK and CDK activity, belonging to the Mps1_cat and Ser/Thr kinase families. The gene is associated with nuclear chromosome segregation, MCC assembly, and protein localization to the kinetochore. It has been connected to regulation of cell division, spindle orientation, microtubule dynamics, centromere localization, and nucleocytoplasmic transport. Additional associations include positive regulation of anabolism, negative regulation of phosphate metabolism and glycogen anabolism, downregulation of calcium-mediated signaling and macroautophagy, and protein destabilization. The product localizes to the kinetochore, cytoplasm, nucleus, cytosol, cellular bud neck, and CDK holoenzyme complex. Studies of related genes in other species link the family to mitotic checkpoint control.