HH3 — Schizosaccharomyces pombe 972h-

Summary

SPBC1105.11C, also known as HH3 or hht3, encodes a histone H3/CENP-A family protein with a histone-fold domain. It is annotated as a structural constituent of chromatin and binds nucleosomal DNA. In Schizosaccharomyces pombe, this gene is associated with centromere localization, kinetochore assembly, and mitotic metaphase chromosome alignment, as well as heterochromatin boundary formation and centromeric silencing. It is linked to mating-type switching, DNA damage response, and cell cycle progression through S phase and anaphase. Phenotypic associations include altered cell cycle timing, increased sporulation rate, decreased hypoosmotic stress resistance, and increased gamma ray resistance. The protein localizes to the nucleosome, kinetochore, and heterochromatin regions including subtelomeric and centric heterochromatin. Studies of related genes in other species connect the family to chromosome segregation and kinetochore function.