NIME — Schizosaccharomyces pombe 972h-

Summary

SPAPB2B4.03, also known as NIME or cig2 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a cyclin protein belonging to the cyclin A/B-like family, with cyclin-dependent protein serine/threonine kinase activator and regulator activities. This gene is associated with the regulation of mitotic and meiotic cell cycle transitions, including G1/S and G2/M phase progression, pre-RC assembly, and mRNA stabilization. It is linked to negative regulation of ascospore formation and meiotic cell cycle switching. The protein localizes to microtubule organizing centers, spindle pole bodies, the meiotic spindle, and the mitotic spindle midzone. Phenotypic associations include delayed metaphase-anaphase transition, G2/M arrest, increased chitin deposition, decreased replicative and chronological lifespan, and reduced vegetative growth. Related genes in other species link the family to G2/M-specific cell cycle control.