GAP1 — Schizosaccharomyces pombe 972h-

Summary

SPAP7G5.06 (GAP1, per1) on chromosome 1 of Schizosaccharomyces pombe encodes an uncharacterized amino-acid permease belonging to the APC_YAT and amino-acid permease families. The gene product has L-arginine and L-lysine transporter activity and is associated with the transport of basic amino acids, including L-lysine, L-leucine, and L-arginine import into cells. It is associated with cell-cell fusion, regulation of growth, Ras protein signal transduction, nitrogen utilization, replication fork arrest, cytokinesis regulation, nucleosome assembly, digestion, and cellular stress responses. The protein localizes to the plasma membrane at cell tips, medial membrane band, Golgi membrane, endoplasmic reticulum, and vacuole. Phenotypic associations include altered nutrient uptake, cell cycle progression, endocytosis, sporulation, adhesion, and hydrostatic pressure resistance. Studies of related genes in other species link the family to phosphate content and oxidative stress response.