rad26 — Schizosaccharomyces pombe 972h-

Summary

SPAC9E9.08, designated rad26 on chromosome 1 of Schizosaccharomyces pombe 972h-, encodes a protein of the DNA damage checkpoint Lcd1 family. The gene is associated with the DNA integrity checkpoint, the DNA replication checkpoint, and regulation of double-strand break repair and DNA repair. It is linked to nucleotide metabolism, recombinational repair, and multiple DNA repair pathways including BER, GGR, TC-NER, and UVER. Rad26 is associated with cell cycle phase, specifically G2 phase, and with microtubule destabilization and bundling, as well as spindle pole body separation. The encoded product localizes to the nucleus, the ATR-ATRIP complex, and chromosome telomeric repeat regions, and is also associated with centromeric silencing.