ARK1 — Schizosaccharomyces pombe 972h-

Summary

SpARK1 (ARK1, SPAC8F11.04) on chromosome 1 of Schizosaccharomyces pombe encodes a U3 snoRNP-associated protein with a ribosomal uL1-like domain and RNA-binding activity. The gene is associated with regulation of chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, chromosome condensation, chromosome biorientation, telophase, meiosis II, and the spindle checkpoint. It is also linked to TORC2 signaling, microtubule shortening, galactose-specific flocculation, and cellular homeostasis. The protein localises to the nucleolus, nucleus, and preribosome. Phenotypic associations include delayed G2 phase and cytokinesis, decreased endocytosis, abnormal filamentous and pseudohyphal growth, increased polyploidy, and altered pheromone sensitivity and cell fusion. Related genes in other species are linked to cell membrane stability and protein content.