CNH1 — Schizosaccharomyces pombe 972h-

Summary

SPAC977.10 (CNH1, also known as sod2) in Schizosaccharomyces pombe 972h- on chromosome 1 encodes a sodium:hydrogen exchanger belonging to the Na+/H+ antiporter family, with potassium transporter activity. The gene is associated with sodium ion export, cellular sodium and potassium ion homeostasis, regulation of membrane potential, proton transport, and oxidative phosphorylation. It is linked to the MAPK cascade, DNA damage checkpoint, apoptotic process, and cell pH reduction. Localisation evidence places the product at the plasma membrane, particularly cell tips, and the perinuclear ER membrane. Associations with traits include photosynthetic rate and sodium concentration. Phenotypic connections involve increased ionic stress resistance, altered respiratory and fermentative metabolism, increased cell death, arrested vegetative growth, and abnormal cell cycle progression through G2/M. Related genes in other species link the family to potassium content and oxidative stress response.