MPH1 — Schizosaccharomyces pombe 972h-

Summary

SPAC9.05, also known as MPH1 or fml1 on chromosome 1 of Schizosaccharomyces pombe, encodes a DEAD/DEAH-box DNA/RNA helicase with ATP-dependent 3'-5' DNA helicase activity, four-way junction helicase activity, and flap-structured DNA binding. The product is a member of the FANCM/Mph1-like helicase family. MPH1 is associated with multiple DNA repair processes, including recombinational interstrand cross-link repair, replication fork reversal, and double-strand break repair via synthesis-dependent strand annealing. It is linked to meiotic strand displacement, negative regulation of strand invasion, and Okazaki fragment processing. The protein localizes to the FANCM-MHF complex, nucleolus, and sites of double-strand breaks. Phenotypic associations include abnormal cell cycle progression, altered mating type switching, absent X-ray and UV resistance, decreased lifespan, delayed sporulation, and abnormal chromosome segregation and meiotic recombination.