DLH1 — Schizosaccharomyces pombe 972h-

Summary

SPAC8E11.03C (DLH1, also known as dmc1) in Schizosaccharomyces pombe 972h- on chromosome 1 encodes a RecA-family recombinase with ATPase, DNA-binding and Sae3-Mei5 complex-binding activities. The gene is associated with meiotic strand invasion, resolution of recombination intermediates, meiotic prophase I, meiotic chromosome organization, and response to ionizing radiation. It localizes to condensed nuclear chromosomes, centromere complexes, sites of double-strand breaks, the nuclear envelope, chromatin, cytosol and nucleus. Phenotypic associations include absent meiotic recombination and sporulation efficiency, altered cell cycle progression through G1/S and metaphase-anaphase transitions, delayed exponential-phase growth, and abnormal spore germination. The gene is linked to SAE3, MND1, HOP2, HED1 and MEI5. Studies of related genes in other species connect it to oxidative stress response.