MCB — Schizosaccharomyces pombe 972h-

Summary

SPAC8C9.03 (MCB/cgs1) on chromosome 1 of Schizosaccharomyces pombe encodes a cAMP-dependent protein kinase regulatory subunit, a member of the cAMP_dep_PK_reg_su family. The product binds cAMP and the PKA catalytic subunit, and exhibits cAMP-dependent protein kinase inhibitor activity. This gene is associated with glucose detection and response, negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling, and regulation of cell division, mitosis, and CDK activity. It is linked to downregulation of nuclear division and Ras protein signal transduction, positive regulation of asexual sporulation, and regulation of cytoplasmic mRNA processing body assembly. The protein localizes to the cAMP-dependent protein kinase complex, cytoplasm, nucleus, plasma membrane, and chromatin. Phenotypic associations include decreased cell cycle progression through G2/M, increased virulence, and abnormal chromosome segregation. Studies of related genes in other species link the family to pathogenicity and virulence.