SKN7 — Schizosaccharomyces pombe 972h-

Summary

SPAC8C9.14 (symbol SKN7, preferred name prr1) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a protein with a response regulator receiver domain and a heat shock factor DNA-binding domain, and has phosphorelay response regulator activity, DNA-binding transcription activator activity, and transferase activity. This gene is associated with redox sensing, response to salt, singlet oxygen, and hydrogen peroxide, as well as cellular thermotolerance, mitotic cell cycle control, cell size control, MAPK cascade, and regulation of the ER unfolded protein response. It is linked to oxidative stress response and phenotypes including absent oxidative stress resistance, increased thermotolerance, abnormal flocculation and biofilm formation, altered cell cycle progression, and increased mating efficiency. The protein localises to the nucleus, cytoplasm, chromatin, and RNA polymerase II transcription regulator complex.