alp7 — Schizosaccharomyces pombe 972h-

Summary

alp7 (SPAC890.02C) on chromosome 1 of Schizosaccharomyces pombe encodes a TACC-family protein that binds microtubules. The gene product is associated with spindle localization, microtubule nucleation, and organization of astral and cytoplasmic microtubules. It is linked to mitotic processes including anaphase spindle elongation, chromosome movement to the spindle pole, spindle assembly, and spindle elongation during prophase. Additional associations include meiotic centromere clustering, microtubule shortening, attachment of spindle microtubules to mitotic chromosomes, and protein transport along microtubules to the kinetochore. The protein localizes to the mitotic spindle pole, microtubule minus-ends, cytoplasmic microtubule bundles, the TACC/TOG complex, and the outer kinetochore, among other sites.