sen1 — Schizosaccharomyces pombe 972h-

Summary

SPAC6G9.10C (sen1) in Schizosaccharomyces pombe 972h- encodes a helicase with 5'-3' RNA and DNA helicase activity, 5' flap endonuclease activity, and dsDNA-dependent ATPase activity, belonging to the SEN1_N and DNA2/NAM7-like domain families. The gene is associated with transcription termination, R-loop processing, Okazaki fragment processing during mitotic DNA replication, replication fork reversal and processing, nonsense-mediated mRNA decay, RNA 3'-end processing, tRNA metabolism, intra-S DNA damage checkpoint effector processes, and regulation of mRNA stability in response to oxidative stress. It is also linked to RNAi-mediated heterochromatin assembly at centromeres, RNAi-like chromatin silencing, and mating-type region heterochromatin. The protein localizes to replication forks, the DNA helicase A complex, the RNA-directed RNA polymerase complex, nucleolar chromatin, nuclear bodies, mitochondrial nucleoids, and telomeric repeat regions. Studies of related genes in other species link the family to RNA helicase and nuclease functions.