slp1 — Schizosaccharomyces pombe 972h-

Summary

slp1 (SPAC821.08C) on chromosome 1 of Schizosaccharomyces pombe encodes a Cdc20/Fizzy family protein with WD40 repeats and ubiquitin ligase activator activity. It binds the anaphase-promoting complex and histones, and acts as a transcription corepressor. The gene is associated with the mitotic spindle checkpoint, chromosome biorientation, and the metaphase/anaphase transitions of both mitosis and meiosis I and II. It also links to MCC assembly, centromere localization, and positive regulation of ascospore formation. Phenotypic associations include premature or delayed anaphase progression, G1/S and G2/M phase transitions, meiotic arrest, increased sporulation, decreased lifespan, and abnormal chromosome segregation. The protein localizes to the kinetochore, mitotic spindle, spindle pole body, cyclosome, and chromatin. Studies of related genes in other species connect the family to turgor pressure.