ace2 — Schizosaccharomyces pombe 972h-

Summary

SPAC6G10.12C (ace2) on chromosome 1 of Schizosaccharomyces pombe encodes a C2H2-type zinc-finger protein with DNA-binding transcription activator activity, RNA polymerase II-specific, and 14-3-3 protein binding activity. The gene is associated with positive regulation of antisense RNA transcription, septum digestion after cytokinesis, and septin ring disassembly and assembly. It is linked to mating projection assembly, bipolar bud site selection, cell adhesion involved in single-species biofilm formation, and regulation of division septum assembly. Additional associations include cellular responses to acidic pH, calcium ions, and metals, as well as calcineurin-mediated signaling pathways, DNA condensation, and upregulation of filamentous growth and cell-substrate adhesion. The protein localizes to the cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.