RTS1 — Schizosaccharomyces pombe 972h-

Summary

SPAC6F12.12 (symbol RTS1, also known as par2) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with protein phosphatase activator activity and protein binding, bridging functions. It belongs to the PP2A_B56 regulatory subunit family and contains ARM-type fold domains. The gene is associated with numerous cell cycle processes including DNA replication termination, meiotic sister chromatid cohesion, the spindle checkpoint, septum positioning, and traversing the mitotic cell cycle start control point. It localizes to the PP2A complex, inner kinetochore, meiotic spindle, centromere complex, mitotic actomyosin contractile ring, and spindle pole body. Phenotypic associations include decreased cell cycle progression rate, decreased autophagy and pexophagy, increased mating type switching, absent X-ray resistance, abnormal sporulation efficiency, and decreased hypoosmotic stress resistance. Studies of related genes in other species link the family to oxidative stress response and potassium concentration.