ADR1 — Schizosaccharomyces pombe 972h-

Summary

SPAC6F12.02 (symbol ADR1, preferred name rst2) on chromosome 1 of Schizosaccharomyces pombe encodes a transcription factor with both DNA-binding transcription activator and repressor activities specific to RNA polymerase II. The gene is associated with carbon catabolite repression, glucose response, and regulation of carbon utilization, as well as gluconeogenesis, the retrograde response, and the SAPK signaling pathway. It is linked to uracil anabolism, citrate and glutamate metabolism, the oxidative pentose pathway, and negative regulation of flocculation. The encoded protein localizes to the nucleus, nucleoplasm, chromatin, heterochromatin, cytoplasm, and cytosol. Studies of related genes in other species link the family to reduced virulence.