ESA1 — Schizosaccharomyces pombe 972h-

Summary

SPAC637.12C (ESA1, also known as mst1) on chromosome 1 of Schizosaccharomyces pombe encodes a MYST family histone acetyltransferase with multiple acyltransferase activities, including histone H3K4, H4K12, crotonyltransferase, butyryltransferase and 2-hydroxyisobutyryltransferase functions. The protein contains a MYST_HAT domain, Tudor-knot, zinc finger MYST, chromo and chromo-shadow domains, and binds chromatin and zinc. ESA1 is associated with chromatin decompaction, DNA repair-dependent chromatin remodeling, transcription elongation, chromosome condensation, spindle checkpoint function, DNA damage checkpoint, telomeric and rDNA heterochromatin silencing, negative regulation of gene expression, positive regulation of triglyceride biosynthesis, macroautophagy, and secondary metabolite regulation. It localises to the Piccolo histone acetyltransferase complex, SWR-C, centric heterochromatin, sites of double-strand breaks, chromatin and the nucleus. Phenotypic associations include altered cell cycle progression through G1/S and G2/M transitions, sporulation rate, prion inheritance, nucleophagy, mitophagy, endocytosis, nuclear export, and chemical resistance.