CEF1 — Schizosaccharomyces pombe 972h-

Summary

SPAC644.12 (symbol CEF1, also known as cdc5) in Schizosaccharomyces pombe encodes a protein containing Myb and SANT/Myb domains characteristic of the CDC5L/Cef1 family, and is annotated with DNA-binding molecular function. The gene is associated with cell cycle transition, G2 phase, M phase, interphase, metaphase, mitotic exit, meiosis I and II, spindle assembly, nuclear division, nuclear movement, and nuclear import. It is linked to the Prp19 complex and spliceosome complex, and localises to the nucleus, cytoplasm, and cytosol. Phenotypic associations include cell cycle progression in metaphase arrested, abnormal spindle morphology, increased telomere length, decreased X-ray resistance, abnormal meiosis and sporulation, increased biofilm formation, and absent or increased mating response. Studies of related genes in other species link the family to reduced virulence and auxin content.