KOG1 — Schizosaccharomyces pombe 972h-

Summary

SPAC57A7.11 (symbol KOG1, also known as mip1) on chromosome 1 of Schizosaccharomyces pombe encodes a Raptor family protein containing Raptor_N, WD40 repeat and ARM-type fold domains. The gene product binds PTS2 and mediates protein bridging. KOG1 is associated with TORC1 signaling, regulation of cell growth, autophagy, response to nutrient and amino acid levels, desumoylation, sumoylation, peroxisome matrix protein import, cell cycle control including G1 phase and meiosis, and cellular response to starvation. It localizes to TORC1, cytoplasm, nucleus, nucleolar chromatin, peroxisomal lumen and fungal-type vacuole membrane. Phenotypic associations include absent alkaline pH resistance, increased necrotic cell death, decreased endocytosis, increased fermentative growth, abnormal replicative lifespan, premature or delayed cell cycle progression, and absent nuclear fusion during mating. Studies of related Kog1 proteins in other species link the family to TORC1 growth control complex function.