MYO1 — Schizosaccharomyces pombe 972h-

Summary

SPAC4A8.05C (MYO1, myp2) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a myosin motor protein with calcium-dependent ATPase activity, microfilament motor activity, calmodulin binding, F-actin binding, small GTPase binding, and ATP binding. It is associated with endomembrane organization, actin filament bundle retrograde transport, vesicle transport along actin filaments, spindle pole body separation, Golgi division, centromere separation, abscission, organelle inheritance, nuclear migration during mitotic telophase, actomyosin contractile ring assembly, peroxisome inheritance, spindle orientation, and spindle breakdown. The gene is linked to salt response and phenotypes including absent or decreased septum formation, decreased cytokinesis, abnormal chromosome segregation, absent cell fusion, abnormal mating response, and altered prion inheritance. It localizes to the myosin V complex, myosin filament, LINC complex, formin-nucleated actin cable, cortical cytoskeleton, and transport vesicles.