SSU72 — Schizosaccharomyces pombe 972h-

Summary

SPAC3G9.04 (SSU72) on chromosome 1 of Schizosaccharomyces pombe encodes a CTD phosphatase with RNA polymerase II C-terminal domain S5 phosphatase activity, protein tyrosine phosphatase activity, and protein serine/threonine phosphatase activity (EC 3.1.3.16). The gene is associated with mRNA 3'-end processing, transcriptional start site selection, termination of RNA polymerase II transcription (both poly(A)-coupled and exosome-dependent), sno(s)RNA transcription, and cotranscriptional 3' processing. It is linked to meiotic chromosome separation, regulation of chromatin silencing at centromere, heterochromatin island assembly, and intracellular phosphate homeostasis. Phenotypic associations include abnormal cell cycle progression (G1/S phase transition increased duration, G2 phase delayed, metaphase premature, telophase premature), decreased chromosome segregation, abnormal spore wall formation, septum formation, cytokinesis, and increased silencing. The protein localizes to the nucleus, cytosol, chromatin, and the mRNA cleavage and polyadenylation specificity factor complex.