FEN1 — Schizosaccharomyces pombe 972h-

Summary

SPAC3G6.06C, also known as FEN1 or rad2, encodes a flap endonuclease with 5'-3' exonuclease activity, belonging to the XPG/Rad2 family. This enzyme is associated with DNA metabolism, including Okazaki initiator RNA removal, recombinational repair, meiotic mismatch repair, and ultraviolet excision repair. It localizes to the nucleus, nucleolus, nucleoplasm, mitochondria, and sites of double-strand breaks. The gene is associated with stem cell development, cellularization, oogenesis, embryogenesis, meiotic prophase I, and response to bleomycin and radiation. Phenotypic associations include altered cell cycle progression, abnormal mating type switching, increased gamma ray resistance, and delayed vegetative growth. Studies of related genes in other species link the family to oxidative stress response.