mis4 — Schizosaccharomyces pombe 972h-

Summary

SPAC31A2.05C (mis4) in Schizosaccharomyces pombe 972h- encodes a protein with cohesin loader activity and ATPase activator activity, binding double- and single-stranded DNA and chromatin. The protein belongs to the Scc2/Nipped-B family and contains a Cohesin_HEAT domain. Mis4 is associated with the establishment and maintenance of sister chromatid cohesion, mitotic metaphase, centromere separation and localization, chromosome condensation, chromatin looping, spindle checkpoint function, spindle elongation, sumoylation, and cell cycle phases including G1 and M phase. It is also linked to replication-born double-strand break repair by sister chromatid exchange. The gene product localizes to the Mis4-Ssl3 cohesin loading complex, SMC loading complex, heterochromatin islands, nuclear chromosome, chromatin, cytosol, and nucleus. Studies of related genes in other species link the family to sister chromatid cohesion.