NUC2 — Schizosaccharomyces pombe 972h-

Summary

SPAC3A12.05C (NUC2, also known as taf2) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a TBP-associated factor 2 protein, a component of the TFIID complex with transcription cis-regulatory region binding, and chromatin binding. The gene is associated with mitotic cell cycle processes including metaphase, anaphase, chromosome separation, sister chromatid separation, condensation, spindle elongation, and mitotic exit, as well as chromatin silencing and transcription initiation from Pol II promoters. It localizes to the TFIID complex, chromatin, nucleus, cytosol, and cell division site. Phenotypic associations include delayed metaphase progression, abnormal shmoo formation, increased vegetative growth, decreased gamma ray and osmotic stress resistance, increased sporulation efficiency, increased chitin deposition, increased transposable element transposition, and decreased alkaline pH and hydrostatic pressure resistance. Studies of related genes in other species link the family to oxidative stress response.