DBP2 — Schizosaccharomyces pombe 972h-

Summary

SPAC2G11.12 (DBP2, preferred name rqh1) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with RecQ-family domains, including a DNA helicase ATP-dependent RecQ domain, and has ATP-dependent 3'-5' DNA helicase, RNA helicase, and four-way junction helicase activities, and binds G-quadruplex DNA, snoRNA, mRNA, chromatin, and zinc. The gene is associated with responses to ionizing radiation and UV, resolution of mitotic and meiotic recombination intermediates, regulation of DNA repair, alternative mRNA splicing, nuclear RNA surveillance, and positive regulation of translation. It localizes to the nuclear replication fork, telomeric repeat region, P-bodies, stress granules, and the RecQ helicase-Topo III complex. Phenotypic associations include altered mitotic recombination, sporulation efficiency, cell cycle progression through G1/S and G2/M transitions, increased gamma ray resistance, increased thermotolerance, delayed vegetative growth, and increased fermentative growth.