TBP — Schizosaccharomyces pombe 972h-

Summary

SPAC29E6.08 (symbol TBP, preferred name tbp1) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes a TATA-box-binding protein, a core component of the transcription factor TFIID, TFIIA, TFIIIB and RNA polymerase I transcription regulator complexes. The product possesses DNA-binding, chromatin-binding and general transcription factor activities, and is annotated to TFIIA-class transcription factor binding, RNA polymerase II core promoter sequence-specific DNA binding, and RNA polymerase III general initiation factor activity. It is associated with transcription initiation from all three nuclear RNA polymerase promoters, preinitiation complex assembly, DNA condensation, programmed cell death, mitotic recombination, cell cycle progression through G1/S and metaphase/anaphase, meiosis, mating-type switching, shmoo formation, pheromone sensitivity and production, desiccation resistance, ribophagy, adhesion, polyploidy, X-ray resistance, and transposable element transposition. Related genes in other species link the family to RNA polymerase I and III transcription factor complex function.