DIS3 — Schizosaccharomyces pombe 972h-

Summary

SPAC2C4.07C (DIS3, dis32) in Schizosaccharomyces pombe encodes a ribonuclease with 3'-5' exoribonuclease, RNA endonuclease, and poly(U) binding activities, and is a core component of both the nuclear and cytoplasmic exosome (RNase complex). The gene is associated with RNA surveillance, including nuclear and cytoplasmic mRNA catabolic processes, exonucleolytic trimming to generate mature 5.8S rRNA, and termination of RNA polymerase II transcription. It is linked to regulation of G1/G0 transition, mitotic sister chromatid separation, and spindle breakdown. Phenotypic associations include abnormal cell cycle progression through G1/S, delayed exit from G0, decreased meiosis, increased virulence, and altered prion inheritance. The protein localises to the nucleolus, nucleoplasm, P-bodies, stress granules, and the cellular bud neck, and is also associated with response to iron and intracellular mRNA localisation.